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1.

Vaccinia virus

The type species of ORTHOPOXVIRUS, related to COWPOX VIRUS, but whose true origin is unknown. It has been used as a live vaccine against SMALLPOX. It is also used as a vector for inserting foreign DNA into animals. Rabbitpox virus is a subspecies of VACCINIA VIRUS.

Year introduced: 1963

2.

protein kinase 2, Vaccinia virus [Supplementary Concept]

amino acid sequence in first source

Date introduced: October 9, 1995

3.

H5R protein, Vaccinia virus [Supplementary Concept]

an early-late 22-kDa protein that migrates at 35-kDa on SDS-PAGE; from vaccinia virus; amino acid sequence in first source

Date introduced: March 10, 1995

4.

early transcription factor protein, Vaccinia virus [Supplementary Concept]

virus-encoded heterodimer; amino acid sequence given in first source

Date introduced: July 10, 1990

5.

L1R protein, Vaccinia virus [Supplementary Concept]

MW 25 kDa; specifically associated with one or more of the membranes enveloping various infectious forms of vaccinia virus virions; has been sequenced

Date introduced: July 12, 1994

6.

p37 protein, Vaccinia virus [Supplementary Concept]

has been sequenced

Date introduced: January 10, 1994

7.

GAAP protein, vaccinia virus [Supplementary Concept]

amino acid sequence in first source

Date introduced: March 24, 2007

8.

I1 protein, vaccinia virus [Supplementary Concept]

required for assembly of mature virions; amino acid sequence in first source; GenBank M35027

Date introduced: December 22, 1997

9.

DNA polymerase, vaccinia virus [Supplementary Concept]

a 110-116 kDa protein isolated from vaccinia virus-infected cells; has an inherent 3'-5' exonuclease activity; amino acid sequence has been determined

Date introduced: December 23, 1994

10.

42kDa protein, Vaccinia virus [Supplementary Concept]

amino acid sequence given in first source

Date introduced: June 11, 1992

11.

VB1R protein, Vaccinia virus [Supplementary Concept]

a 34 kDa polypeptide that functions as a serine/threonine protein kinase; has been sequenced

Date introduced: May 13, 1992

12.

immunodominant protein p35, vaccinia virus [Supplementary Concept]

amino acid sequence given in first source

Date introduced: February 26, 1992

13.

complement-control protein, Vaccinia virus [Supplementary Concept]

amino acid sequence has been determined; secreted from infected cells; has sequence similarities to members of a gene family that includes complement control proteins

Date introduced: December 26, 1990

14.

capping enzyme, vaccinia virus [Supplementary Concept]

consists of EC 2.7.7.50, EC 2.1.1.56, & RNA triphosphatase

Date introduced: January 22, 1981

15.

Dual Specificity Phosphatase 3

A dual specificity phosphatase subtype that plays a role in intracellular signal transduction by inactivating MITOGEN-ACTIVATED PROTEIN KINASES. It has specificity for EXTRACELLULAR SIGNAL-REGULATED MAP KINASES.

Year introduced: 2008(1994)

16.

D8L protein, vaccinia virus [Supplementary Concept]

potentially useful in vaccines; N-terminal amino acid sequence in first source

Date introduced: April 13, 2008

17.

A27 protein, vaccinia virus [Supplementary Concept]

binds glycosaminoglycans to aid virus in binding cells

Date introduced: February 7, 2008

18.

D10 protein, vaccinia virus [Supplementary Concept]

an mRNA decapping enzyme used to control host and viral gene expression

Date introduced: May 13, 2007

19.

A33R protein, Vaccinia virus [Supplementary Concept]

isolated from Vaccinia virus; amino acid sequence in first source

Date introduced: February 15, 2002

20.

envelope H3L protein, Vaccinia virus [Supplementary Concept]

binds cell surface heparan sulfate; amino acid sequence in first source

Date introduced: April 4, 2000

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