Improving the prevention, diagnosis and clinical management of sepsis
Sepsis arises when the body’s response to any infection injures its own tissues and organs. If not recognized early and managed promptly, it can lead to septic shock, multiple organ failure and death. It is a serious complication of infection in all countries and particularly in low- and middle-income countries it represents a major cause of maternal and neonatal morbidity and mortality.
Although a precise estimate of the global epidemiological burden of sepsis is difficult to ascertain, some scientific publications reported that it affects more than 30 million people worldwide every year, potentially leading to 6 million deaths. The burden of sepsis is most likely highest in low- and middle-income countries.
Sepsis is frequently underdiagnosed at an early stage when it is still potentially reversible. In the community setting, it often presents as the clinical deterioration of common and preventable infections. Sepsis also frequently results from infections acquired in health care settings, which are one of, if not the most frequent adverse events during care delivery. As these infections are often resistant to antibiotics, they can rapidly lead to deteriorating clinical conditions.