Review

. 2014 May 30;32(26):3122-7.

doi: 10.1016/j.vaccine.2014.04.021. Epub 2014 Apr 14.

Safety of influenza vaccination during pregnancy: a review of subsequent maternal obstetric events and findings from two recent cohort studies

Collaborators, Affiliations

Collaborators

Vaccine Safety Datalink and Pregnancy and Influenza Project:
Allison Naleway, Michelle Henninger, Brad Crane, Stephanie Irving, James Donahue, Burney Kieke, Deanna Cole, Julianne Gee, Eric Weintraub, Allison Nale-way, Michelle Henninger, Tia Kauffman, Stephanie Irving, Joanna Bulkley, Samantha Kurosky, Nancy Siegel, Pat Shifflett, Sarah Ball, Sam Bozeman, De-Kun Li, Jeanette Ferber, Roxana Odouli, Lynd-say Avalos, Mark Thompson, Jennifer Williams, Janet Cragan, Leslie Sokolow, Sue Reynolds, David Shay

Affiliations

¹ Center for Health Research, Kaiser Permanente Northwest, 3800 N. Interstate Ave., Portland, OR 97227, USA. Electronic address: allison.naleway@kpchr.org.
² Center for Health Research, Kaiser Permanente Northwest, 3800 N. Interstate Ave., Portland, OR 97227, USA. Electronic address: stephanie.irving@kpchr.org.
³ Center for Health Research, Kaiser Permanente Northwest, 3800 N. Interstate Ave., Portland, OR 97227, USA. Electronic address: michelle.henninger@kpchr.org.
⁴ Division of Research, Northern California Kaiser Permanente, 2000 Broadway, Oakland, CA 94612, USA. Electronic address: de-kun.li@kp.org.
⁵ Abt Associates, 55 Wheeler Street, Cambridge, MA 02138, USA. Electronic address: pat_shifflett@abtassoc.com.
⁶ Abt Associates, 55 Wheeler Street, Cambridge, MA 02138, USA. Electronic address: sarah_ball@abtassoc.com.
⁷ Centers for Disease Control and Prevention, 1600 Clifton Rd., Atlanta, GA 30333, USA. Electronic address: znv8@cdc.gov.
⁸ Centers for Disease Control and Prevention, 1600 Clifton Rd., Atlanta, GA 30333, USA. Electronic address: jdc9@cdc.gov.
⁹ Centers for Disease Control and Prevention, 1600 Clifton Rd., Atlanta, GA 30333, USA. Electronic address: dzg2@cdc.gov.
¹⁰ Centers for Disease Control and Prevention, 1600 Clifton Rd., Atlanta, GA 30333, USA. Electronic address: isq8@cdc.gov.

PMID: 24742490
PMCID: PMC5898611
DOI: 10.1016/j.vaccine.2014.04.021

Free PMC article

Review

Safety of influenza vaccination during pregnancy: a review of subsequent maternal obstetric events and findings from two recent cohort studies

Allison L Naleway et al. Vaccine. 2014.

Free PMC article

. 2014 May 30;32(26):3122-7.

doi: 10.1016/j.vaccine.2014.04.021. Epub 2014 Apr 14.

Collaborators

Vaccine Safety Datalink and Pregnancy and Influenza Project:
Allison Naleway, Michelle Henninger, Brad Crane, Stephanie Irving, James Donahue, Burney Kieke, Deanna Cole, Julianne Gee, Eric Weintraub, Allison Nale-way, Michelle Henninger, Tia Kauffman, Stephanie Irving, Joanna Bulkley, Samantha Kurosky, Nancy Siegel, Pat Shifflett, Sarah Ball, Sam Bozeman, De-Kun Li, Jeanette Ferber, Roxana Odouli, Lynd-say Avalos, Mark Thompson, Jennifer Williams, Janet Cragan, Leslie Sokolow, Sue Reynolds, David Shay

Affiliations

¹ Center for Health Research, Kaiser Permanente Northwest, 3800 N. Interstate Ave., Portland, OR 97227, USA. Electronic address: allison.naleway@kpchr.org.
² Center for Health Research, Kaiser Permanente Northwest, 3800 N. Interstate Ave., Portland, OR 97227, USA. Electronic address: stephanie.irving@kpchr.org.
³ Center for Health Research, Kaiser Permanente Northwest, 3800 N. Interstate Ave., Portland, OR 97227, USA. Electronic address: michelle.henninger@kpchr.org.
⁴ Division of Research, Northern California Kaiser Permanente, 2000 Broadway, Oakland, CA 94612, USA. Electronic address: de-kun.li@kp.org.
⁵ Abt Associates, 55 Wheeler Street, Cambridge, MA 02138, USA. Electronic address: pat_shifflett@abtassoc.com.
⁶ Abt Associates, 55 Wheeler Street, Cambridge, MA 02138, USA. Electronic address: sarah_ball@abtassoc.com.
⁷ Centers for Disease Control and Prevention, 1600 Clifton Rd., Atlanta, GA 30333, USA. Electronic address: znv8@cdc.gov.
⁸ Centers for Disease Control and Prevention, 1600 Clifton Rd., Atlanta, GA 30333, USA. Electronic address: jdc9@cdc.gov.
⁹ Centers for Disease Control and Prevention, 1600 Clifton Rd., Atlanta, GA 30333, USA. Electronic address: dzg2@cdc.gov.
¹⁰ Centers for Disease Control and Prevention, 1600 Clifton Rd., Atlanta, GA 30333, USA. Electronic address: isq8@cdc.gov.

PMID: 24742490
PMCID: PMC5898611
DOI: 10.1016/j.vaccine.2014.04.021

Abstract

Pregnant women and their infants are vulnerable to severe disease and secondary complications from influenza infection. For this reason, annual influenza vaccination is recommended for all pregnant women in the United States. Women frequently cite concerns about vaccine safety as a barrier to vaccination. This review describes the safety of inactivated influenza vaccination during pregnancy with a focus on maternal obstetric events, including hypertensive disorders, gestational diabetes, and chorioamnionitis. Included in the review are new findings from two studies which examined the safety of seasonal inactivated influenza vaccination during pregnancy. The first study enrolled 641 pregnant women during the 2010-2011 season and prospectively followed them until delivery or pregnancy termination. The second study enrolled 1616 pregnant women during the 2010-2011 influenza season, and followed the women and their infants for six months after delivery. No associations between inactivated influenza vaccination and gestational diabetes, gestational hypertension, preeclampsia/eclampsia, or chorioamnionitis were observed in either cohort. When considered as a whole, these studies should further reassure women and clinicians that influenza vaccination during pregnancy is safe for mothers.

Keywords: Influenza vaccine; Obstetric outcomes; Pregnancy; Safety.

Conflict of interest statement

Conflict of interest: The findings and conclusions reported in this article are those of the authors and do not necessarily represent the views of CDC, Abt Associates, AHIP, or Kaiser Foundation Research Institute. Each author reviewed and approved the final version of the article. A.N. reports receiving research funding from GlaxoSmithKline for an unrelated study. None of the remaining authors report any conflicts of interest.

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Safety of influenza vaccination during pregnancy: a review of subsequent maternal obstetric events and findings from two recent cohort studies

Collaborators

Affiliations

Safety of influenza vaccination during pregnancy: a review of subsequent maternal obstetric events and findings from two recent cohort studies

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Conflict of interest statement

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