DPA has offices in five states, along with an office of national affairs in Washington, DC, which works for federal reform, and an office of legal affairs in California.

DPA's state offices are in California, Colorado, New Jersey, New Mexico and New York.

In the states, DPA has played a pivotal role in more than twenty successful ballot initiatives concerning medical marijuana, asset forfeiture reform and treatment instead of incarceration for nonviolent drug offenders.