UBE2C

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UBE2C
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1I7K, 4YII, 5A31
Identifiers
Aliases	UBE2C, UBCH10, dJ447F3.2, ubiquitin conjugating enzyme E2 C
External IDs	MGI: 1915862 HomoloGene: 5096 GeneCards: UBE2C
EC number	2.3.2.24
Gene ontology Molecular function • transferase activity • nucleotide binding • ubiquitin protein ligase activity • ubiquitin-protein transferase activity • protein binding • ATP binding • ubiquitin conjugating enzyme activity • ubiquitin protein ligase binding • ubiquitin-like protein ligase binding Cellular component • cytoplasm • nucleoplasm • anaphase-promoting complex • cytosol • plasma membrane • ubiquitin ligase complex Biological process • free ubiquitin chain polymerization • ubiquitin-dependent protein catabolic process • regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • exit from mitosis • positive regulation of exit from mitosis • protein K11-linked ubiquitination • cell division • protein K48-linked ubiquitination • regulation of mitotic metaphase/anaphase transition • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • cell cycle • anaphase-promoting complex-dependent catabolic process • positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition • proteasome-mediated ubiquitin-dependent protein catabolic process • positive regulation of ubiquitin protein ligase activity • protein ubiquitination involved in ubiquitin-dependent protein catabolic process • protein ubiquitination Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11065	68612
Ensembl	ENSG00000175063	ENSMUSG00000001403
UniProt	O00762 Q5TZN3	Q9D1C1
RefSeq (mRNA)	NM_001281741 NM_001281742 NM_007019 NM_181799 NM_181800 NM_181801 NM_181802 NM_181803	NM_026785
RefSeq (protein)	NP_001268670 NP_001268671 NP_008950 NP_861515 NP_861516 NP_861517 NP_008950.1	NP_081061
Location (UCSC)	Chr 20: 45.81 – 45.82 Mb	Chr 2: 164.77 – 164.78 Mb
PubMed search	[1]	[2]
Wikidata
View/Edit Human View/Edit Mouse

Ubiquitin-conjugating enzyme E2 C is a protein that in humans is encoded by the UBE2C gene.^[3][4]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for the destruction of mitotic cyclins and for cell cycle progression. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.^[4]

References[edit]

Further reading[edit]

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