CD49a is an integrin alpha subunit. It makes up half of the α1β1 integrin duplex.
This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding.[3]
References[edit]
Further reading[edit]
- Virtanen I, Korhonen M, Kariniemi AL, et al. (1991). "Integrins in human cells and tumors.". Cell Differ. Dev. 32 (3): 215–27. PMID 2099238. doi:10.1016/0922-3371(90)90034-T.
- Plenz GA, Deng MC, Robenek H, Völker W (2003). "Vascular collagens: spotlight on the role of type VIII collagen in atherogenesis.". Atherosclerosis. 166 (1): 1–11. PMID 12482545. doi:10.1016/S0021-9150(01)00766-3.
- Clover J, Dodds RA, Gowen M (1992). "Integrin subunit expression by human osteoblasts and osteoclasts in situ and in culture.". J. Cell. Sci. 103 (1): 267–71. PMID 1429908.
- Bodary SC, McLean JW (1990). "The integrin beta 1 subunit associates with the vitronectin receptor alpha v subunit to form a novel vitronectin receptor in a human embryonic kidney cell line.". J. Biol. Chem. 265 (11): 5938–41. PMID 1690718.
- Sonnenberg A, Linders CJ, Modderman PW, et al. (1990). "Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8.". J. Cell Biol. 110 (6): 2145–55. PMC 2116116
. PMID 1693624. doi:10.1083/jcb.110.6.2145.
- Belkin VM, Belkin AM, Dol'nikova AE, et al. (1992). "[Isolation and characteristics of ligand specificity of VLA-1 integrin from human smooth muscles]". Biokhimiia. 56 (12): 2198–206. PMID 1807406.
- Bank I, Roth D, Book M, et al. (1991). "Expression and functions of very late antigen 1 in inflammatory joint diseases.". J. Clin. Immunol. 11 (1): 29–38. PMID 1827128. doi:10.1007/BF00918792.
- Tabibzadeh S (1990). "Evidence of T-cell activation and potential cytokine action in human endometrium.". J. Clin. Endocrinol. Metab. 71 (3): 645–9. PMID 2144294. doi:10.1210/jcem-71-3-645.
- Tawil NJ, Houde M, Blacher R, et al. (1990). "Alpha 1 beta 1 integrin heterodimer functions as a dual laminin/collagen receptor in neural cells.". Biochemistry. 29 (27): 6540–4. PMC 2710132 . PMID 2169872. doi:10.1021/bi00479a028.
- Belkin VM, Belkin AM, Koteliansky VE (1990). "Human smooth muscle VLA-1 integrin: purification, substrate specificity, localization in aorta, and expression during development.". J. Cell Biol. 111 (5 Pt 1): 2159–70. PMC 2116325 . PMID 2229189. doi:10.1083/jcb.111.5.2159.
- MacDonald TT, Horton MA, Choy MY, Richman PI (1990). "Increased expression of laminin/collagen receptor (VLA-1) on epithelium of inflamed human intestine.". J. Clin. Pathol. 43 (4): 313–5. PMC 502365 . PMID 2341567. doi:10.1136/jcp.43.4.313.
- Takada Y, Strominger JL, Hemler ME (1987). "The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis.". Proc. Natl. Acad. Sci. U.S.A. 84 (10): 3239–43. PMC 304844 . PMID 3033641. doi:10.1073/pnas.84.10.3239.
- Hemler ME, Huang C, Schwarz L (1987). "The VLA protein family. Characterization of five distinct cell surface heterodimers each with a common 130,000 molecular weight beta subunit.". J. Biol. Chem. 262 (7): 3300–9. PMID 3546305.
- Kono Y, Yang S, Letarte M, Roberts EA (1996). "Establishment of a human hepatocyte line derived from primary culture in a collagen gel sandwich culture system.". Exp. Cell Res. 221 (2): 478–85. PMID 7493648. doi:10.1006/excr.1995.1399.
- Eglinton BA, Roberton DM, Cummins AG (1995). "Phenotype of T cells, their soluble receptor levels, and cytokine profile of human breast milk.". Immunol. Cell Biol. 72 (4): 306–13. PMID 7806264. doi:10.1038/icb.1994.46.
- Salter DM, Godolphin JL, Gourlay MS (1995). "Chondrocyte heterogeneity: immunohistologically defined variation of integrin expression at different sites in human fetal knees.". J. Histochem. Cytochem. 43 (4): 447–57. PMID 7897185. doi:10.1177/43.4.7897185.
- Pfaff M, Aumailley M, Specks U, et al. (1993). "Integrin and Arg-Gly-Asp dependence of cell adhesion to the native and unfolded triple helix of collagen type VI.". Exp. Cell Res. 206 (1): 167–76. PMID 8387021. doi:10.1006/excr.1993.1134.
- Briesewitz R, Epstein MR, Marcantonio EE (1993). "Expression of native and truncated forms of the human integrin alpha 1 subunit.". J. Biol. Chem. 268 (4): 2989–96. PMID 8428973.
- Langholz O, Röckel D, Mauch C, et al. (1996). "Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrins.". J. Cell Biol. 131 (6 Pt 2): 1903–15. PMC 2120685 . PMID 8557756. doi:10.1083/jcb.131.6.1903.
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PDB gallery
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1ck4: CRYSTAL STRUCTURE OF RAT A1B1 INTEGRIN I-DOMAIN.
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1mhp: Crystal structure of a chimeric alpha1 integrin I-domain in complex with the Fab fragment of a humanized neutralizing antibody
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1pt6: I domain from human integrin alpha1-beta1
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1qc5: I Domain from Integrin Alpha1-Beta1
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1qcy: THE CRYSTAL STRUCTURE OF THE I-DOMAIN OF HUMAN INTEGRIN ALPHA1BETA1
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2b2x: VLA1 RdeltaH I-domain complexed with a quadruple mutant of the AQC2 Fab
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External links[edit]
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| Cytoadhesin receptor: |
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| Fibrinogen receptor: |
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| Fibronectin receptor: |
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| Leukocyte-adhesion receptor: |
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| Very late antigen receptor: |
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