Buspirone HCL

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Avoid taking MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before and after treatment with this medication. Ask your doctor when to start or stop taking this medication.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: alcohol, antidepressants (e.g., SSRIs such as fluoxetine, tricyclic antidepressants such as amitriptyline/nortriptyline, trazodone), benzodiazepines (e.g., lorazepam, clonazepam, diazepam), haloperidol, drugs that slow down the removal of buspirone from your body by affecting certain liver enzymes including azole antifungals (e.g., itraconazole, ketoconazole), ritonavir, nefazodone, diltiazem, drugs that speed up the removal of buspirone from your body by affecting certain liver enzymes including rifamycins (e.g., rifampin, rifabutin), corticosteroids (e.g., dexamethasone), and certain anticonvulsants (e.g., phenytoin, phenobarbital).

Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (e.g., diphenhydramine), anti-seizure medications (e.g., valproic acid), medicine for sleep or anxiety (e.g., alprazolam, flurazepam, zolpidem), muscle relaxants, narcotic pain relievers (e.g., codeine), psychiatric medications (e.g., risperidone).

This medication may interfere with certain medical/laboratory tests (including brain scan for Parkinson's disease), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.