Byzantine Empire
At last the menace of simultaneous war on two fronts threatened Justinian’s plans. During the 550s, his armies were to prove equal to the challenge, but a major disaster prevented them from so doing between 541 and about 548. The disaster was the bubonic plague of 541–543, the first of those shocks, or traumas, mentioned earlier, that would eventually transform East Rome into the medieval Byzantine Empire. The plague was first noted in Egypt, and from there it passed through Syria and Asia Minor to Constantinople. By 543 it had reached Italy and Africa, and it may also have attacked the Persian armies on campaign in that year. In East Asia the disease has persisted into the 20th century, providing medical science with an opportunity to view its causes and course. Transmitted to humans by fleas from infected rodents, the plague attacks the glands and early manifests itself by swellings (buboes) in armpit and groin, whence the name bubonic. To judge from Procopius’ description of its symptoms at Constantinople in 542, the disease then appeared in its more virulent pneumonic form, wherein the bacilli settle in the lungs of the victims. ... (200 of 32,247 words)The crisis of midcentury