Christianity
The reference in the Kartēr inscription to two sects of Christians continues the indications from Syriac sources that Christianity had by that time (the second half of the 3rd century) gained a firm footing in the lands of the Tigris and the Euphrates, where it was strongest among the Aramaic-speaking communities. Ultimately, Christian missionary effort came to expand over the whole of Iran and even beyond. As long as the Roman Empire remained pagan, the Christian communities of Iran lived undisturbed by persecution, while the Christians themselves showed outspoken hostility toward such heterodox sects as the Manichaeans and the Gnostic followers of Marcion (the Marcionites) and Bardesanes, who existed side by side with them. Once the emperor Constantine I (the Great; reigned 306–337) made Christianity the official religion of the Roman world, the Iranian Christians were drawn to feel a certain sympathy for their foreign coreligionists, and political significance came to be attached by the Sāsānian rulers to these religious connections with an often hostile foreign power. After 339 the Christians of Iran were subjected to severe persecutions at the hands of Shāpūr II and his successors. Nonetheless, substantial Christian communities survived in parts of Iran long after the end of the Sāsānian dynasty.