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Indication
Synvisc-One® (hylan G-F 20) is indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy and simple analgesics, e.g., acetaminophen.

Important Safety Information for Synvisc-One
Before trying Synvisc-One, tell your doctor if you have had an allergic reaction, such as swelling of the face, tongue or throat, respiratory difficulty, rash, itching or hives to SYNVISC or any hyaluronan-based products.

View the complete prescribing information for Synvisc-One (PDF).

Knee Pain: Three Signs It's Time for a Different Knee Pain Treatment

Osteoarthritis knee pain can be frustrating and unpredictable. But there's no reason to just live with the pain. In fact, there are good reasons to find another treatment sooner rather than later.

1. Do you plan around your knee pain?

You shouldn't have to give things up due to pain. Be honest with yourself and your doctor about the effect knee pain is having on your activities.

2. Is knee pain keeping you from exercising?

Exercise is a key component of any treatment plan for osteoarthritis knee pain. If your knee pain is preventing you from exercising, that is a sign you may need to talk to your doctor about what treatment options are available.

3. Are your current treatments falling short?

If you've tried exercise and over the counter pain relievers, and haven't found enough knee pain relief, don't give up. There are other options besides surgery. Talk to your doctor about finding the right treatment for you.

Ready to Try Something Different?

Your doctor is counting on you to be honest about your level of pain and let him or her know when you're ready to discuss other treatment options.

If you've tried exercise and over-the-counter pain relievers, but haven't found enough relief for your osteoarthritis knee pain, a viscosupplement injection like Synvisc-One® (hylan G-F 20) could help.

Viscosupplements add to your natural joint fluid to help lubricate the joint to keep it working smoothly and act as a shock absorber to cushion bones when you move.

They're different from steroid injections, which are used to reduce inflammation and relieve pain.

Ask your doctor about getting up to six months of osteoarthritis knee pain relief.

You don't need to be in constant pain to be ready for a different treatment. Synvisc-One can relieve osteoarthritis knee pain for up to 6 months with just 1 injection.

Get a free information kit about OA knee pain relief with Synvisc-One
Learn more about getting up to 6 months of knee pain relief
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Important Safety Information for Synvisc-One

Before trying Synvisc-One, tell your doctor if you have had an allergic reaction, such as swelling of the face, tongue or throat, respiratory difficulty, rash, itching or hives to SYNVISC or any hyaluronan-based products. Should not be used in patients with an infected knee joint, skin disease or infection around the area where the injection will be given, or circulatory problems in the legs.

Synvisc-One is only for injection into the knee, performed by a doctor or other qualified health care professional. Synvisc-One has not been tested to show pain relief in joints other than the knee. Tell your doctor if you are allergic to products from birds – such as feathers, eggs or poultry – or if your leg is swollen or infected.

Synvisc-One has not been tested in children (≤21years old), pregnant women or women who are nursing. You should tell your doctor if you think you are pregnant or if you are nursing a child.

Talk to your doctor before resuming strenuous weight-bearing activities after treatment.

The side effects sometimes seen after Synvisc-One include (<2% each): pain, swelling, heat, redness, and/or fluid build-up in or around the knee. Tell your doctor if you experience any side effects after treatment with Synvisc One.

© 2013 Genzyme Corporation, a Sanofi Company.
All rights reserved. Synvisc-One, SYNVISC and GENZYME are registered trademarks of Genzyme Corporation.
US.SYN.13.04.022

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