MAL gene is a candidate tumor suppressor gene that maps to chromosome2q11.1thatcodes for a novel hydrophobic protein involved in membrane trafficking processes.Objeetive: To detect MAL in colorectal cancer and adjacent normal tissues.Analysisthe expression of MAL in different stages,different pathological types,different degreeof differentiation of colorectal cancer tissues.Explore related clinical significance of theexpression of MAL gene in [...]
24
Apr
Influent Factors and Clinical Significance of Lymphangiogenesis in Gastric Adenocarcinoma
Objective:This study aimed at investigating on the impact factors such asclinicopathologic factors metastatic lymph node ratio and Ki-67expression forlymphangiogenesis in gastric cancer. And then study on prognosis of patients wouldbe investigated too.Methods:The expression of monoclonal antibody D2-40, Ki-67in primary lesion of103patients with gastric cancer was detected by immunohistochemical staining aswell as their cIinicopathologic profiles. The [...]
24
Apr
Relativity of FGFR3and MMP-9Expression in Bladder Transitional Cell Carcinoma
Background: Bladder cancer is the most common urological tumorsin our country.And most of them are transitional cell carcinoma.Recently study show that FGFR3and MMP-9play an important role in oncogenesis、growth、invasion、metastasisand angiogenesis in the bladder transitional cell carcinoma (BTCC). FGFR3andMMP-9may be a important markers and potential therapeutic targets in BTCC.Objective: To investigate the expression of FGFR3and MMP-9in BTCC [...]
24
Apr
Invesitgated Effect of Heparan Sulfate in Anti-human Breast Cancer
Aims:1. To investigated HS synthesis of MCF-10A Inhibition the breast cancer cells.2. To investigated HS on the inhibition of breast cancer tumors in mice transplanted.3. In endoplasmic reticulum (ER) stress state, the expression of Hpa in breast cancercells.4. In endoplasmic reticulum (ER) stress state, the effect of HS Inhibited the breastcancer cells.Methords:Part Ⅰ Cell experiment1. [...]
24
Apr
Integrated Expression Profiling and ChIP-seq Analyses of the Growth Inhibition Response Program of the Androgen Receptor
The androgen receptor (AR) plays important roles in the development of male phenotype and in different human diseases including prostate cancers. The AR can act either as a promoter or a tumor suppressor depending on cell types. The AR proliferative response program has been well studied, but its prohibitive response program has not yet been [...]
24
Apr
Effects of Epigallocatechin-3-gallate (EGCG) on Colon Cancer in Vivo and Notch Signaling Pathway
【Objectives】To study the anticancer effect of different doses of epigallocatechin-3-gallate (EGCG) on colon cancer with subcutaneous translocation fluorescence in situ animal model and Notch signaling pathway related genes.【Method】Using the human colon cancer cell line HT-29to establish the colon cancer subcutaneous translocation fluorescence in situ transplantation model. Thirty-nine nude mice were randomly divided into four groups, [...]
24
Apr
The Functionalizing of Single-Walled Carbon Nanotubes and the Preliminary Study on Its Applications As Deliveries of Three Kinds of Sirna on Anti-Breast Cancer<
Single-walled carbon nanotubes (SWNT) is a kind of nano-materials with regular structure, stable chemical property. As the ability to enter cell by endocytosis, SWNT with suitable size is potential drug carriers. SWNT has obvious advantages because of its targeting of tumor tissue. siRNA can effectively silence the gene expression of tumor over and interrupt the [...]
24
Apr
Cell Cycle and Apoptosis Effect of Different Phosphorylation Sites on Two Domain of Survivn on Breast Cancer
Survivin is the smallest member of apoptosis inhibitor gene (inhibitor of apoptosis protein, IAP) family in mammalian cell. In addition, Survivin is a mitotic regulator and involves in cell cycle regulation as a member of Chromosomal Passenger Complex (CPC). Different domain of Survivin may perform different physiological functions. Survivin has become a new cancer drug [...]
24
Apr
Syndrome Type of Esophageal Cancer Cells with Chemotherapy in Patients Experimental Study of Drug Sensitivity
Esophageal cancer is one of common gastrointestinal clinic in China have high morbidityand mortality, a serious threat to people’s health. Treatment of esophageal cancer are surgery,radiotherapy, chemotherapy, biological therapy and traditional Chinese medicine and othermethods; surgery, although the preferred treatment, but many patients are already in advancedwhen found, lost the chance of surgery, chemotherapy remains [...]