ObjectiveTo analyze the important factors affecting the prognosis of patients with gastric carcinoma and study the expression of p53 protein in human gastric carcinoma and the relation to clinicopathology and prognosis.Methods1. Data collection Collected 132 cases of patients with gastric cancer resected in our hospital from June 2004 to October 2004.The expression of p53 protein [...]
18
Jan
Effects of Sodium Butyrate on the Proliferation and Differentiation of Human Gastric Cancer Cell Line AGS
BACKGROUND & OBJECTIVE: Sodium butyrate (NaBT) is a kind of short chain fatty acids (SCFA), which is produced in the large bowel of human by anaerobic bacterial fermentation of dietary fiber. Many researches indicated that NaBT could inhibit the proliferation and induce the differentiation of various tumorous cells, including hepatoma, ovarian cancer and colon carcinoma. [...]
18
Jan
Anti-tumor Effects of Dendritic Cells Induced by OK-432 Combined with Freeze-thaw Tumor Cell Lysates on Forestomach Carcinoma-bearing Mice
Objective To prepare the mouse forestomach carcinoma vaccines based on dendritc cells(DCs) from mouse bone marrow monocytes induced by OK-432 combined with freeze-thaw tumor cells lysates and to observe its anti-tumor effect in vivo so as to evaluate the applied value in gastric cancer immunotherapy for the clinical treatment later.Methods Mouse bone marrow monocytes(BMMCs) were [...]
18
Jan
CpG Island Methylator Phenotype Involving Tumor Suppressor Genes Located on Chromosome 3p in Non-Small Cell Lung Cancer
Objective: We addressed the question of whether CpG island methylator phenotype (CIMP) status could correlate with non-small cell lung cancer (NSCLC) and be a good biomarker for early detection and evaluating prognosis of NSCLC. Methylation profiles for eight tumor suppressor genes (TSGs) harbored in chromosome 3p were detected in 60 NSCLC tissues, 60 paired normal [...]
18
Jan
Study on the Expression and Relation of COX-2 and VEGF in Oral Lichen Planus
Objective:This study aims to investigate the role of COX-2 and VEGF in the genesis of oral squamous cell carcinoma by means of evaluation on their expression in oral lichen planus,leukoplakia and squamous cell carcinoma.Methods:The expression of COX-2 and VEGF were studied in 33 cases of oral lichen planus(OLP),35 cases of oral leukoplakia(OLK),31 cases of oral [...]
18
Jan
Effects of EGCG on Biology of Human Hair Follicles and Cultured Dermal Papilla Cells(DPCs) and the Expression of HIF-1α in Human Hair Follicle and Cultured Der
The hair follicle, a unique characteristic organ of mammals, represents a stem cell-rich, prototypic neuroectodermal-mesodermal interaction system. A unique feature of hair follicles is their cyclical behavior. Starting with anagen, the hair follicle and its shaft pass through catagen, telogen and finally exogen. The dermal papilla is necessary to both induce and maintain the hair [...]
18
Jan
Study on the Relationship between the Irradiation Dose and Volume in Radiation-induced Lung Injury
Objective:To investigate the relationships between the irradiation dose and volume in radiation-induced lung injury through setting–up the model of graded volume irradiation of the rat lung.Methods:ELEKTA precise 2.03 treatment plan system was applied to calculate the irradiation dose and volume.Functional,biochemical,histopathological and CT changes were compared biweekly after single irradiation of the regional lung.Results:1.Rat model of [...]
18
Jan
Clinical Observation of Kushen Injection in Prevention of Acute Radiation Proctitis
Objective:To evaluate the clinical effects of Kushen injection in prevention of acute radiation proctitis.Methods:Eighty-nine patients with cervical carcinoma were randomized into two groups,from June 2006 to October 2007,46 cases were treated with Kushen injection combined with radiotherapy in compounded group and the remained 43 cases treated with radiotherapy only.All patients in the two groups received [...]
18
Jan
Design, Synthesis and Biological Evaluation of Benzosultams as Novel Tubulin Inhibitors
Cancer is a common and frequently-occurring disease that threatens the human life seriously and causes mortality only second to cardiovascular vessel diseases. Tumor cells proliferate rapidly, and the cell cycle is obviously shorter than normal cell. The tubulin/microtubule system is an integral component of the cytoskeleton. Microtubules are highly dynamic structures that play a critical [...]
18
Jan
Oxaliplatin: Investigation of Safety in Heated Intra-peritoneal Perfusion and Pharmacokinetic Study
Objective: To establish the determination method of L-OHP in vivo and in vitro by HPLC, to considerate the security of L-OHP administrating in heated intra-operative intra-peritoneal therapy of digestive system neoplasm’s patients. To analysis pharmacokinetic parameters between difference dosage in two regimens by intravenous infusion, and monitoring the changes of platinum bounding with blood-proteins in [...]
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