Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.
DRUG CLASS AND MECHANISM: Pentosan is a semi-synthetic (man-made) drug used for treating the symptoms of interstitial cystitis. Interstitial cystitis is a condition, usually of unknown cause, in which there is inflammation of the bladder that most frequently causes pelvic pain and frequent urination. The exact mechanism whereby pentosan reduces the symptoms of interstitial cystitis also is unknown; however, scientists believe that pentosan may coat the lining of the bladder and prevent irritating substances in the urine from reaching the cells of the lining.
PRESCRIPTION: Yes
GENERIC AVAILABLE: No
PREPARATIONS: Capsules: 100 mg.
STORAGE: Store at room temperature between 15-30°C (59-86°F).
PRESCRIBED FOR: Pentosan is used for relieving bladder pain caused by interstitial cystitis.
DOSING: The recommended dose of pentosan is 100 mg three times daily. The effect of food on absorption of pentosan is unknown, and, therefore, it should be taken at least one hour before or two hours after meals so that food cannot retard its absorption.
DRUG INTERACTIONS: Drug interaction studies have not been conducted with pentosan.
PREGNANCY: Studies with pentosan have not been conducted in pregnant women.
NURSING MOTHERS: Studies of pentosan have not been conducted in nursing mothers.
SIDE EFFECTS: The most common side effects of pentosan are stomach upset, diarrhea, nausea, headache, rash, abdominal pain, hair loss and dizziness. Some patients may abnormalities of liver tests in the blood.
Interstitial cystitis (IC) is an inflammatory disease of the bladder that can cause ulceration and bleeding of the bladder's lining and can lead to scarring and stiffening of the bladder. Symptoms of interstitial cystitis may vary among individuals and may even vary with time in the same individual.
The urinary system consists of the kidneys,
ureters, bladder, and urethra. The kidneys, a
pair of purplish-brown organs, are located below the ribs toward the middle of
the back. The kidneys remove water and waste from the blood in the form of
urine, keeping a stable balance of salts
and other substances in the blood. The kidneys also produce erythropoietin, a
hormone that stimulates the formation of red blood cells. Narrow tubes called ureters carry urine from the kidneys to the
bladder, a triangle-shaped, muscular chamber in the lower abdomen. Like a balloon, the bladder's muscular, elastic
walls relax and expand to store urine and contract and flatten when urine is
emptied through the urethra. The typical adult bladder can store about 1 ½
cups of urine.
Adults urinate about 1 ½ quarts of urine each day. The amount of
urine varies depending on the fluids and foods a person consumes. The volume...