influenza nasal vaccine, FluMist
Pharmacy Author: Omudhome Ogbru, PharmD
Medical and Pharmacy Editor: Jay W. Marks, MD
GENERIC NAME: Influenza vaccine live, Intranasal
BRAND NAME: FluMist
DRUG CLASS AND MECHANISM: FluMist is a nasal vaccine that protects against
infection with the influenza virus or the "flu." FluMist contains live influenza
virus that has been weakened so that it causes minimal or no symptoms. When
FluMist is inhaled, the body responds to the weakened viruses in FluMist by
developing antibodies that fight influenza viruses. These antibodies protect
against later infections by the naturally-occurring influenza virus. FluMist is
effective only against the strains of influenza virus that are included in it,
and the strains of virus change from year to year. FluMist has no effect on the
flu once infection has begun. FluMist should be given shortly before the flu
season begins to allow time for antibodies to be produced and for protection
throughout the entire flu season. FluMist does not prevent 2009 H1N1 (swine flu)
virus infection. The FDA approved FluMist in June 2003.
PRESCRIPTION: Yes.
GENERIC AVAILABLE: No.
PREPARATIONS: Intranasal Spray: prefilled single use intranasal spray, 0.2 ml
STORAGE: FluMist should be stored refrigerated between 2-8 C (35-46 F).
PRESCRIBED FOR: FluMist is used for preventing influenza virus infections
(flu) in individuals 2 to 49 years of age.
DOSING: Children 2 to 8 years of age who have not previously received.
FluMist should be given 2 doses of 0.2 ml one month apart. Children 2 to 8 years
of age, who previously received FluMist and adults 9 to 49 years of age, should
be given 1 dose (0.2 ml) each season. FluMist is administered by inhaling
through the nose and is not given by injection. Half of a single dose (0.1 ml)
should be inhaled into each nostril while in a standing position.
Since FluMist contains viruses that are likely to cause the flu in the
upcoming season, FluMist developed for previous seasons will not be effective
and should not be used.
DRUG INTERACTIONS: Children 5 to 17 years of age who are receiving
aspirin
therapy should not be given FluMist because of the association between aspirin,
influenza infection and Reye's syndrome.
Use of FluMist together with antiviral drugs that are active against the
influenza virus has not been evaluated. Since there is a potential for these
agents to reduce the effectiveness of FluMist (by preventing infection with the
weakened viruses in FluMist), such antiviral agents should not be administered
until 2 weeks after FluMist therapy, and FluMist should not be administered
until 48 hours after antiviral therapy is discontinued.
PREGNANCY: FluMist should not be given to
pregnant women.
NURSING MOTHERS: Use of FluMist during breast feeding has not been adequately
evaluated, and it is not known whether FluMist is excreted in
breast milk.
SIDE EFFECTS: The most common side effects of FluMist are cough, runny nose,
nasal congestion, sore throat, headache, restlessness, muscle aches, tiredness
or weakness and fever. Hypersensitivity reactions have also been reported.
FluMist should not be administered to individuals with asthma because it may
increase wheezing.
Reference: FluMist Prescribing Information, 2009
Last Editorial Review: 11/23/2009
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