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Hormone Therapy
(Estrogen Therapy, Estrogen/Progestin Therapy)

Medical Author: Ruchi Mathur, MD
Medical Editors: William C. Shiel Jr., MD, FACP, FACRDennis Lee, MD
Revising Medical Author: Carolyn Crandall, MD, MS, FACP

In this article, the term "hormone therapy" or "HT" is replacing the outdated terminology "hormone replacement therapy" or "HRT."

What is menopause?

Menopause is the stage in a woman's life when menstruation stops and she can no longer bear children. During menopause, the body produces less of the female hormones, estrogen and progesterone. After menopause, the lower hormone levels cause the monthly menstrual periods to stop and gradually eliminate the possibility of becoming pregnant. These fluctuations in hormone levels can also cause troublesome symptoms, such as hot flashes (a sudden sensation of warmth, sometimes associated with flushing, and often followed by sweating) and sleep disturbance. Sometimes women experience other symptoms, such as vaginal dryness.

While many women encounter little or no trouble during menopause, others endure moderate to severe discomfort.

Does menopause cause bone loss?

The lower estrogen levels of menopause can lead to progressive bone loss that is especially rapid in the first five years after menopause. Some bone loss in both men and women is normal as people age. Lack of estrogen after menopause adds another strain on the bones in addition to the usual age-related bone loss. When bone loss is severe, a condition called osteoporosis weakens bones and renders them susceptible to breaking. For more, please read the osteoporosis article.

What are estrogen therapy and hormone therapy (HT)?

Estrogen, in pill, patch, or gel form, is the single most effective therapy for suppressing hot flashes.

The term estrogen therapy, or ET, refers to estrogen administered alone. Because ET alone can cause uterine cancer (endometrial cancer) (see below), a progestin is administered together with estrogen in women who have a uterus to eliminate the increased risk. Thus, the term estrogen/progestin therapy, or EPT, refers to a combination of estrogen and progestin therapy, as is given to a woman who still has a uterus. This method of prescribing hormones is also known as combination hormone therapy.

The term hormone therapy (HT) is a more general term that is used to refer to either administration of estrogen alone (women who have had a hysterectomy), or combined estrogen/progestin therapy (women with a uterus).

All forms of hormone therapy (HT) that are FDA-approved for therapy of hot flashes are similarly effective in suppressing hot flashes.




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Hormone Therapy

Introduction to menopause and hot flashes

Women frequently ask what symptoms they can anticipate during menopause. In reality, each woman experiences menopause differently. While one woman is certain that insomnia is a symptom of menopause for her, another is certain that joint aches are her primary symptom of menopause. Doctors are not even able to tell women what to expect because research into the symptoms of menopause has not yet established just how menopause causes many of its symptoms. For example, medical science cannot explain how the declining hormone levels of menopause could cause joint aches.

Menopause is not a disease but a natural transition, yet many of the symptoms of menopause also may be caused by diseases. We are not always certain which symptoms are due to menopause, and women differ in their symptoms. How, then, do we decide when women underg...

Read the Alternative Treatments for Hot Flashes of Menopause article »



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