14 Feb, 11 | by BMJ Group
JAMA 9 Feb 2011 Vol 305
569 If I were a woman, the things I would most fear from breast cancer surgery would be arm lymphoedema and recurrence of the cancer. Does one have to be balanced against the other? Common sense would suggest that the more axillary lymph nodes you dissect, the less likely it is that the cancer will recur. But last week we learned that micrometastases in the lymph nodes show very little correlation with survival, and this week we learn from this study that in women with invasive breast cancer and sentinel node metastases, survival is the same whether axillary node dissection is performed or not. The risk of arm lymphoedema goes down from 75% to 25%. So this trial continues the trend to less mutilating surgery for breast cancer begun by Sir Geoffrey Keynes in the 1920s, as I keep reminding readers in the hope that they will secure for themselves a second-hand copy of his autobiography. In The Gates of Memory, Keynes invites Henry James to Edwardian Cambridge, collects Blake manuscripts, grabs casualties under shellfire, pioneers blood transfusion, revolutionises breast cancer management, goes to the ballet, organises surgical services for the wartime RAF, cures myasthenia gravis with thymectomy, has medical students dig him a swimming pool and is criticised for his lapses in seventeenth century bibliography. more…