Fluorescence profiles of normal human peripheral blood lymphocytes unstained (blue histogram) or stained with PerCP-Cy5.5 anti-human CD45 (LCA) (purple histogram).
Contents: CD45 PerCP-Cy5.5 Catalog Number: 9045-9459 Formulation: aqueous buffer, 0.09% sodium azide, contains stabilizer if necessary Clone: 2D1 Concentration: 5 µl (0.125 µg)/test (a test is defined as the amount that will stain 1x106 cells in 100 µL) Host/Isotype: Mouse IgG1, k HLDA Workshop: III Storage Conditions: Store at 2-8°C. Do not freeze. Light-sensitive material.
The 2D1 monoclonal antibody reacts with all isoforms of human CD45, also known as Leukocyte Common Antigen (LCA). CD45 is expressed by all hematopoietic cells excluding circulating erythrocytes and platelets. The cytoplasmic portion of CD45 has tyrosine phosphatase enzymatic activity and plays an important role in activation of lymphocytes.
References
Procedures for the Collection of Diagnostic Blood Specimens by Venipuncture (H3-A6), 3rd Edition published by the National Committee for Clinical Laboratory Standards.
Schwinzer R. Cluster report: CD45/CD45R. In: Knapp W, Dörken B, Gilks WR, et al., eds. Leucocyte Typing IV: White Cell Differentiation Antigens. New York, NY: Oxford University Press; 1989:628-634.
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