By David D. Ginty
ESI Special Topics,
January 2004
Citing URL - http://www.esi-topics.com/nhp/2004/january-04-DavidGinty.html
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David D. Ginty answers a few questions about this month's
new hot paper in the field of Neuroscience & Behavior.
From
•>>January 2004
Field:
Neuroscience & Behavior
Article Title: Function and regulation of CREB family transcription factors in the nervous system
Authors: Lonze, BE;Ginty, DD
Journal: NEURON
Volume: 35
Page: 605-623
Year: AUG 15 2002
* Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Dept
Neurosci, Baltimore, MD 21205 USA.
* Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Dept
Neurosci, Baltimore, MD 21205 USA.
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 Why
do you think your paper is highly cited?
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“
CREB stands for cyclic-AMP- >responsive element-binding protein.„”
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This paper was highly cited because it reviews the CREB
literature, which is of interest to a very broad audience. This is
because CREB family transcription factors have been implicated in
many processes including development, maintenance, and plasticity of
the nervous system.
Does
it describe a new discovery or a new methodology that's useful to
others?
No, but it summarizes some of the technology, including
invertebrate and mouse genetic approaches, currently being used to
study CREB function.
Could
you summarize the significance of your paper in layman's terms?
(CREB stands for cyclic-AMP- >responsive element-binding
protein.) The
CREB family of proteins are crucial mediators of gene expression
and, in particular, stimulus-dependent gene expression. This review
summarizes the functions of CREB and its close relatives, their
regulation, and their target genes. I think the review is of broad
interest because CREB has, for more than a decade, served as the
prototypical stimulus-dependent transcription factor. And so CREB
serves as a model for understanding how extracellular stimuli, such
as neurotransmitters and growth factors, trigger genetic changes
that underlie long-term cellular responses.
How
did you become involved in this research?
I have a long-standing interest in nerve growth factor signaling.
I became involved in research addressing CREB function and
regulation when, as a postdoctoral fellow with Michael Greenberg of
Harvard Medical School, we found that CREB family members are
mediators of growth factor signalling pathways in neurons.
David Ginty, Ph.D.
Associate Professor of Neuroscience
Department of Neuroscience
Howard Hughes Medical Institute
The Johns Hopkins University School of Medicine
Baltimore, MD, USA
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ESI Special Topics,
January 2004
Citing URL - http://www.esi-topics.com/nhp/2004/january-04-DavidGinty.html
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