The Collaborative Ocular Melanoma Study

The University of Iowa is a participant in the Collaborative Ocular Melanoma Study (COMS), a multicernter randomized trial sponsored by The National Eye Institute and The National Cancer Institute of the National Institutes of Health.

1. Introduction
2. Methods
   1. Intergrader Reliability
   2. COMS Grading Form
3. The COMS Grading Scheme: Graded Features
   1. Macular and Peripapillary Features
      1. Retinal Hemorrhage
      2. Subretinal Hemorrhage
      3. Preretinal Hemorrhage
      4. Vitreous hemorrhage
      5. Cotton wool spots (soft exudates)
      6. Hard exudates (lipid)
      7. Perivascular sheathing
      8. Telangiectasia
      9. Microaneurysms
      10. Laser scars (focal or pan-retinal photocoagulation)
      11. Retinal capillary nonperfusion
      12. Retinal vascular leakage of the macula (Macular edema)
      13. Other lesions
   2. Macular Features
      1. Retinal detachment involving the fovea
      2. Foveal geographic atrophy (GA) of the retinal pigment epithelium (RPE)
   3. Peripapillary Features
      1. Optic disc hemorrhage
      2. Neovascularization of the disc
      3. Optic disc edema
      4. Optic disc pallor
      5. Optic disc hyperfluorescence
4. Links
   1. Visit the COMS site
   2. COMS information at clinicaltrials.gov
      1. Older Information from NEI
   3. About Ocular Melanoma
5. Acknowledgements
6. Contact Us