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Successful Multidisciplinary Therapy for Small Cell Carcinomas Arising from the Extrahepatic Bile Duct

Intern Med. 2015;54(21):2711-5. doi: 10.2169/internalmedicine.54.4603. Epub 2015 Nov 1.

Abstract

A 74-year-old man was diagnosed with small cell carcinoma arising from the extrahepatic bile duct according to a histological examination of the biopsy specimen obtained during endoscopic retrograde cholangiopancreatography. Additionally, bulky hilar lymphadenopathy was observed, and the patient was treated with the combination of radiation and chemotherapy (cisplatin and irinotecan). Post-therapy, he underwent pancreaticoduodenectomy. The histological examination of the resected specimen revealed no residual cancer cells in the bile duct wall and a small amount of cancer cells in only a single lymph node. Due to this multidisciplinary therapy, the patient showed no signs of recurrence 12 months postoperatively.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antineoplastic Agents / administration & dosage
  • Bile Duct Neoplasms / diagnosis*
  • Bile Duct Neoplasms / drug therapy
  • Bile Duct Neoplasms / radiotherapy
  • Bile Duct Neoplasms / therapy*
  • Bile Ducts, Extrahepatic* / diagnostic imaging
  • Camptothecin / administration & dosage
  • Camptothecin / analogs & derivatives
  • Carcinoma, Small Cell / diagnosis*
  • Carcinoma, Small Cell / drug therapy
  • Carcinoma, Small Cell / radiotherapy
  • Carcinoma, Small Cell / therapy*
  • Cholangiopancreatography, Endoscopic Retrograde
  • Cisplatin / administration & dosage
  • Common Bile Duct / pathology*
  • Humans
  • Irinotecan
  • Male
  • Neoplasm Recurrence, Local / prevention & control
  • Pancreaticoduodenectomy* / methods
  • Radiation-Sensitizing Agents / administration & dosage
  • Treatment Outcome

Substances

  • Antineoplastic Agents
  • Radiation-Sensitizing Agents
  • Irinotecan
  • Cisplatin
  • Camptothecin