Article Dans Une Revue
Nature Reviews Neuroscience
Année : 2002
Résumé
In the immature brain, GABA (gamma-aminobutyric acid) is excitatory, and GABA-releasing synapses are formed before glutamatergic contacts in a wide range of species and structures. GABA becomes inhibitory by the delayed expression of a chloride exporter, leading to a negative shift in the reversal potential for choride ions. I propose that this mechanism provides a solution to the problem of how to excite developing neurons to promote growth and synapse formation while avoiding the potentially toxic effects of a mismatch between GABA-mediated inhibition and glutamatergic excitation. As key elements of this cascade are activity dependent, the formation of inhibition adds an element of nurture to the construction of cortical networks.
Domaines
Biologie cellulaire
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https://inserm.hal.science/inserm-00484852
Soumis le : mercredi 19 mai 2010-12:39:40
Dernière modification le : dimanche 26 juin 2022-00:18:59
Archivage à long terme le : mercredi 30 novembre 2016-22:32:07
Dates et versions
- HAL Id : inserm-00484852 , version 1
- DOI : 10.1038/nrn920
- PUBMED : 12209121
Citer
Yehezkel Ben-Ari. Excitatory actions of gaba during development: the nature of the nurture.. Nature Reviews Neuroscience, 2002, 3 (9), pp.728-39. ⟨10.1038/nrn920⟩. ⟨inserm-00484852⟩
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