Sleep deprivation decreases superoxide dismutase activity in rat hippocampus and brainstem
L Ramanathan, S Gulyani, R Nienhuis, JM Siegel - Neuroreport, 2002 - journals.lww.com
Sleep deprivation by the disk-over-water technique results in a predictable syndrome of
physiological changes in rats. It has been proposed that reactive oxygen species (ROS) may
be responsible for some of these effects. A variety of antioxidative enzymes such as
superoxide dismutase (SOD) and glutathione peroxidase (GPx) help to regulate the level of
ROS. In this study we investigated the effects of prolonged (5–11 days) sleep deprivation on
the activities of SOD and GPx as well as the metabolic activity of the mitochondria (using …
physiological changes in rats. It has been proposed that reactive oxygen species (ROS) may
be responsible for some of these effects. A variety of antioxidative enzymes such as
superoxide dismutase (SOD) and glutathione peroxidase (GPx) help to regulate the level of
ROS. In this study we investigated the effects of prolonged (5–11 days) sleep deprivation on
the activities of SOD and GPx as well as the metabolic activity of the mitochondria (using …