Production of superoxide anions by a CNS macrophage, the microglia
CA Colton, DL Gilbert - FEBS letters, 1987 - Wiley Online Library
CA Colton, DL Gilbert
FEBS letters, 1987•Wiley Online LibraryMicroglia have been implicated in both physiological and pathological processes of the
brain. Their possible roles have been compared to those of macrophages and granulocytes.
Here we demonstrate the specific ability of microglia to secrete the superoxide radical ion in
response to a complement activated agent, opsonized zymosan, and to phorbol myristate
acetate. As in other organs, this endogenously produced reactive oxygen intermediate could
have both beneficial and deleterious effects.
brain. Their possible roles have been compared to those of macrophages and granulocytes.
Here we demonstrate the specific ability of microglia to secrete the superoxide radical ion in
response to a complement activated agent, opsonized zymosan, and to phorbol myristate
acetate. As in other organs, this endogenously produced reactive oxygen intermediate could
have both beneficial and deleterious effects.
Microglia have been implicated in both physiological and pathological processes of the brain. Their possible roles have been compared to those of macrophages and granulocytes. Here we demonstrate the specific ability of microglia to secrete the superoxide radical ion in response to a complement activated agent, opsonized zymosan, and to phorbol myristate acetate. As in other organs, this endogenously produced reactive oxygen intermediate could have both beneficial and deleterious effects.