Gα15 and Gα16 couple a wide variety of receptors to phospholipase C (∗)
S Offermanns, MI Simon - Journal of Biological Chemistry, 1995 - ASBMB
The murine G-protein α-subunit Gα 15 and its human counterpart Gα 16 are expressed in a
subset of hematopoietic cells, and they have been shown to regulate β-isoforms of inositide-
specific phospholipase C. We studied the ability of a variety of receptors to interact with Gα
15 and Gα 16 by cotransfecting receptors and G-protein α-subunits in COS-7 cells.
Activation of β 2 adrenergic and muscarinic M 2 receptors in cells expressing the receptors
alone or together with Gα q, Gα 11, or Gα 14 led to a very small stimulation of endogenous …
subset of hematopoietic cells, and they have been shown to regulate β-isoforms of inositide-
specific phospholipase C. We studied the ability of a variety of receptors to interact with Gα
15 and Gα 16 by cotransfecting receptors and G-protein α-subunits in COS-7 cells.
Activation of β 2 adrenergic and muscarinic M 2 receptors in cells expressing the receptors
alone or together with Gα q, Gα 11, or Gα 14 led to a very small stimulation of endogenous …