Expression cloning of GABAB receptors uncovers similarity to metabotropic glutamate receptors
K Kaupmann, K Huggel, J Heid, PJ Flor, S Bischoff… - Nature, 1997 - nature.com
K Kaupmann, K Huggel, J Heid, PJ Flor, S Bischoff, SJ Mickel, G McMaster, C Angst…
Nature, 1997•nature.comGABA (γ-amino-butyric acid), the principal inhibitory neurotransmitter in the brain, signals
through ionotropic (GABAA/GABAC) and metabotropic (GABAB) receptor systems. Here we
report the cloning of GABAB receptors. Photoaffinity labelling experiments suggest that the
cloned receptors correspond to two highly conserved GABAB receptor forms present in the
vertebrate nervous system. The cloned receptors negatively couple to adenylyl cyclase and
show sequence similarity to the metabotropic receptors for the excitatory neurotransmitter L …
through ionotropic (GABAA/GABAC) and metabotropic (GABAB) receptor systems. Here we
report the cloning of GABAB receptors. Photoaffinity labelling experiments suggest that the
cloned receptors correspond to two highly conserved GABAB receptor forms present in the
vertebrate nervous system. The cloned receptors negatively couple to adenylyl cyclase and
show sequence similarity to the metabotropic receptors for the excitatory neurotransmitter L …
Abstract
GABA (γ-amino-butyric acid), the principal inhibitory neurotransmitter in the brain, signals through ionotropic (GABAA/GABAC) and metabotropic (GABAB) receptor systems. Here we report the cloning of GABAB receptors. Photoaffinity labelling experiments suggest that the cloned receptors correspond to two highly conserved GABAB receptor forms present in the vertebrate nervous system. The cloned receptors negatively couple to adenylyl cyclase and show sequence similarity to the metabotropic receptors for the excitatory neurotransmitter L-glutamate.
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