… of cell populations, thereby estimating the proportion of cells harboring each event. We …
TITAN on idealized mixtures, simulating clonal populations from whole-genome sequences taken …

… from whole-genome sequences taken from genomically heterogeneous … tumors that the
inference of CNA and LOH using TITAN critically informs … 2014. High-definition reconstruction of …

… heterogeneous cellular populations including normal and tumour … TITAN: inference of
copy number architectures in clonal cell populations from tumor whole-genome sequence data…

… TITAN: Inference of copy number architectures in clonal cell populations from tumour whole
genome sequence data”… genomic profiles between cell populations (clones) within a tumour. …

… and tumor clones. Next, we apply HATCHet on whole-genome multi-sample DNA sequencing
data … 14 , Battenberg 9 , TITAN 17 , cloneHD 25 —do not attempt to directly infer fractional …

… that quantifies tumor content in cfDNA from 0.1× coverage whole-genome … copy ratios and
copy number between the datatypes, using CNA predicted from the deeper WGS using TITAN …

… of TitanCNA, if data. type=‘LogRatio’, then the S_Dbw internal data consists of copy number
log ratios, … number}) and clonal cluster (z) make up the clusters in the internal evaluation. If …

… infer single-cell copy number profiles and tumor clonal … with matched whole-genome
sequencing (WGS) to create tumor/… this simplest clonal architecture and hence distinguish tumor …

… [30], TITAN [24], cloneHD [25], and Battenberg [23] on 32 tumor … -specific copy numbers (top)
for each of the 4 tumor clones in … -cell whole-genome DNA sequencing data. Recent single-…

… from 38 whole-genome-sequenced small-cell lung-cancer … total clonal copy number and
clonal minor allele copy number, … infer the subclonal architecture of a tumor, clusters of cancer-…