Increased HGF and c-Met in muscle tissues of polymyositis and dermatomyositis patients: beneficial roles of HGF in muscle regeneration
T Sugiura, Y Kawaguchi, M Soejima, Y Katsumata… - Clinical …, 2010 - Elsevier
We investigated the expression of hepatocyte growth factor (HGF), which has mitogenic and
anti-fibrotic activities, in muscle tissue of polymyositis/dermatomyositis (PM/DM) patients, as
well as its functional roles in cultured myoblasts. Immunohistochemistry in muscle from
PM/DM patients revealed that HGF was expressed predominantly on infiltrating
mononuclear cells and that muscle cells expressed the receptor c-met. Cultured myoblasts
produced HGF; which was increased by IL-1α but suppressed by TGF-β and …
anti-fibrotic activities, in muscle tissue of polymyositis/dermatomyositis (PM/DM) patients, as
well as its functional roles in cultured myoblasts. Immunohistochemistry in muscle from
PM/DM patients revealed that HGF was expressed predominantly on infiltrating
mononuclear cells and that muscle cells expressed the receptor c-met. Cultured myoblasts
produced HGF; which was increased by IL-1α but suppressed by TGF-β and …
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