Deletion of parasite immune modulatory sequences combined with immune activating signals enhances vaccine mediated protection against filarial nematodes
SA Babayan, HL Luo, N Gray, DW Taylor… - PLoS Neglected …, 2012 - journals.plos.org
Background Filarial nematodes are tissue-dwelling parasites that can be killed by Th2-
driven immune effectors, but that have evolved to withstand immune attack and establish
chronic infections by suppressing host immunity. As a consequence, the efficacy of a
vaccine against filariasis may depend on its capacity to counter parasite-driven
immunomodulation. Methodology and Principal Findings We immunised mice with DNA
plasmids expressing functionally-inactivated forms of two immunomodulatory molecules …
driven immune effectors, but that have evolved to withstand immune attack and establish
chronic infections by suppressing host immunity. As a consequence, the efficacy of a
vaccine against filariasis may depend on its capacity to counter parasite-driven
immunomodulation. Methodology and Principal Findings We immunised mice with DNA
plasmids expressing functionally-inactivated forms of two immunomodulatory molecules …
[PDF][PDF] Deletion of Parasite Immune Modulatory Sequences Combined with Immune Activating Signals
SA Babayan, H Luo, N Gray, DW Taylor, JE Allen - 2012 - academia.edu
Background: Filarial nematodes are tissue-dwelling parasites that can be killed by Th2-
driven immune effectors, but that have evolved to withstand immune attack and establish
chronic infections by suppressing host immunity. As a consequence, the efficacy of a
vaccine against filariasis may depend on its capacity to counter parasite-driven
immunomodulation. Methodology and Principal Findings: We immunised mice with DNA
plasmids expressing functionally-inactivated forms of two immunomodulatory molecules …
driven immune effectors, but that have evolved to withstand immune attack and establish
chronic infections by suppressing host immunity. As a consequence, the efficacy of a
vaccine against filariasis may depend on its capacity to counter parasite-driven
immunomodulation. Methodology and Principal Findings: We immunised mice with DNA
plasmids expressing functionally-inactivated forms of two immunomodulatory molecules …
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