Applying unmixing to gene expression data for tumor phylogeny inference
R Schwartz, SE Shackney - BMC bioinformatics, 2010 - Springer
Background While in principle a seemingly infinite variety of combinations of mutations
could result in tumor development, in practice it appears that most human cancers fall into a
relatively small number of" sub-types," each characterized a roughly equivalent sequence of
mutations by which it progresses in different patients. There is currently great interest in
identifying the common sub-types and applying them to the development of diagnostics or
therapeutics. Phylogenetic methods have shown great promise for inferring common …
could result in tumor development, in practice it appears that most human cancers fall into a
relatively small number of" sub-types," each characterized a roughly equivalent sequence of
mutations by which it progresses in different patients. There is currently great interest in
identifying the common sub-types and applying them to the development of diagnostics or
therapeutics. Phylogenetic methods have shown great promise for inferring common …
Applying unmixing to gene expression data for tumor phylogeny inference
S Russell - 2010 - agris.fao.org
Background While in principle a seemingly infinite variety of combinations of mutations
could result in tumor development, in practice it appears that most human cancers fall into a
relatively small number of" sub-types," each characterized a roughly equivalent sequence of
mutations by which it progresses in different patients. There is currently great interest in
identifying the common sub-types and applying them to the development of diagnostics or
therapeutics. Phylogenetic methods have shown great promise for inferring common …
could result in tumor development, in practice it appears that most human cancers fall into a
relatively small number of" sub-types," each characterized a roughly equivalent sequence of
mutations by which it progresses in different patients. There is currently great interest in
identifying the common sub-types and applying them to the development of diagnostics or
therapeutics. Phylogenetic methods have shown great promise for inferring common …
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