The industrial production of β-lactam antibiotics by fermentation over the past 50 years is
one of the outstanding examples of biotechnology. Today, the β-lactam antibiotics …

The discovery and development of the β-lactam antibiotics are among the most powerful and
successful achievements of modern science and technology. Since Fleming's accidental …

Twenty-nine strains of Pseudomonas, classified as P. fluorescens biotype D or E or as P.
multivorans, were examined for the production of pyrrolnitrin, an antifungal agent …

The initial discovery of Fleming's contaminating Penicillium fungus and its remarkable
antibacterial properties now date back more than 50 years. Although the Oxford group …

Exogenous tryptophan is metabolized by Pseudomonas aureofaciens to yield pyrrolnitrin [3-
chloro-4-(2′-nitro-3′-chlorophenyl)-pyrrole], an antifungal agent. The ability of this culture …

The application of directed selection techniques and genetic engineering methods for
manipulation of antibiotic-producing microorganisms is generating a new era in industrial …

Analysis of a 13C NMR spectrum of a concentrated broth from Penicillium chrysogenum
fermentation revealed the presence of penicillin V and 6-oxo-piperidine-2-carboxylic acid (1) …

Publisher Summary This chapter reviews genetic and selection methodology that is currently
utilized in the selection, purification, and stabilization of high-productivity mutants as …

A cell-free system of the cephalosporin C fungus, Cephalosporium acremonium, has been
described which conversts penicillin N to a cephalosporin-like material which was …

Mutation and selection work carried out over a number of years has resulted in the
development of superior strains of P. chrysogenum. The lineage of one superior strain …