▪ Abstract Helper T (Th) cell–regulated B cell immunity progresses in an ordered cascade of
cellular development that culminates in the production of antigen-specific memory B cells …

Follicular helper T (Tfh) cells are the class of effector T helper cells that regulates the step-
wise development of antigen-specific B cell immunity in vivo. Deployment of CXCR5+ Tfh …

Follicular helper T (TFH) cells are a class of helper T cells specialized in the cognate control
of antigen-specific B cell immunity. Upon first contact with antigen-primed B cells …

How follicular helper T cells (TFH cells) differentiate to regulate B cell immunity is critical for
effective protein vaccination. Here we define three transcription factor T-bet–expressing …

Effective vaccines induce high-affinity memory B cells and durable antibody responses
through accelerated mechanisms of natural selection. Secondary changes in antibody …

Migration of antigen-activated CD4 T cells to B cell areas of lymphoid tissues is important for
mounting T cell–dependent antibody responses. Here we show that CXC chemokine …

The mechanisms that regulate B cell memory and the rapid recall response to antigen
remain poorly defined. This study focuses on the rapid expression of B cell memory upon …

How vaccines control the development of antigen-specific effector and memory T helper
cells is central to protective immunity but remains poorly understood. Here we found that …

The unfolded protein response (UPR) is a stress response pathway that is driven by the
increased load of unfolded proteins in the endoplasmic reticulum of highly secretory cells …

Blimp-1 is a transcriptional repressor able to drive the terminal differentiation of B cells into
Ig-secreting plasma cells. We have created mice with a B cell-specific deletion of prdm1, the …