Neural stem cells are a self-renewing population that generates the neurons and glia of the
developing brain. They can be isolated, proliferated, genetically manipulated and …

One of the impediments to the treatment of brain tumors (eg, gliomas) has been the degree
to which they expand, infiltrate surrounding tissue, and migrate widely into normal brain …

Hypoxic-ischemic injury is a prototype for insults characterized by extensive tissue loss.
Seeding neural stem cells (NSCs) onto a polymer scaffold that was subsequently implanted …

The study of the basic physiology of the neural precursors generated during brain
development is driven by two inextricably linked goals. First, such knowledge is instrumental …

Stem cells, by virtue of their defining property of self-renewal, represent an unlimited source
of potentially functional human cells for basic research and regenerative medicine. Having …

Stable clones of neural stem cells (NSCs) have been isolated from the human fetal
telencephalon. These self-renewing clones give rise to all fundamental neural lineages in …

To better direct repair following spinal cord injury (SCI), we designed an implant modeled
after the intact spinal cord consisting of a multicomponent polymer scaffold seeded with …

Multipotent neural cell lines were generated via retrovirus-mediated v-myc transfer into
murine cerebellar progenitor cells. When transplanted back into the cerebellum of newborn …

Migration toward pathology is the first critical step in stem cell engagement during
regeneration. Neural stem cells (NSCs) migrate through the parenchyma along …

Neurons undergoing targeted photolytic cell death degenerate by apoptosis. Clonal,
multipotent neural precursor cells were transplanted into regions of adult mouse neocortex …