| Series |
Population Genomics |
|
Population genomics.
|
| Bibliography |
Includes bibliographical references and index. |
| Contents |
Intro; Preface; Contents; Contributors; Part I: Concepts, Technical Advances and Challenges; Technical Advances and Challenges in Genome-Scale Analysis of Ancient DNA; 1 Introduction; 2 The Nature of Ancient DNA; 2.1 Understanding Postmortem DNA Damage Pattern; 2.2 Exogenous DNA Contamination; 3 Ancient DNA Extraction Methods; 3.1 Ancient DNA Extraction from Animal Remains; 3.2 Ancient DNA Extraction from Plants; 4 Next-Generation Sequencing and Library Preparation; 4.1 Double-Stranded Versus Single-Stranded Library Preparation; 4.2 Targeted Enrichment |
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5 Bioinformatic Challenges and Solutions5.1 Authentication of aDNA and Estimation of the Contamination Rate; 5.2 Reconstruction of Ancient Genomes; 5.3 Other Analytical Tools; 6 Conclusions and Future Perspectives; References; Paleoproteomics: An Introduction to the Analysis of Ancient Proteins by Soft Ionisation Mass Spectrometry; 1 Introduction; 2 Soft Ionisation Mass Spectrometry and Proteomics; 3 Paleoproteomes; 3.1 Characterisation of the Bone Proteome; 3.1.1 Bone Collagen; 3.1.2 Non-collagenous Proteins (NCPs) in Bone; 3.2 Information Content of Ancient Bone Proteins |
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3.2.1 Phylogenetic Information Recovery3.2.2 Species Identification; 3.3 Sequence Limitations; 3.4 Age-Related Information from Proteins and their Post-translational Modifications (PTMs); 3.5 Contamination and Sequence Mismatches: A Dinosaur Protein Case Study; 4 Conclusions and Future Perspectives; References; Ancient RNA; 1 Introduction; 2 A Brief History of aRNA Study; 3 Diagenesis; 3.1 Migration and Loss; 3.2 Fragmentation; 3.3 Deamination; 3.4 Cross-linking; 3.5 Enzymatic Breakdown; 4 Perceived Information Value Compared to Ancient DNA; 5 Regulatory RNA; 6 RNA Genomes |
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7 Endogenous Transcriptomics8 Technical Considerations for aRNA; 8.1 Isolation of aRNA; 8.2 NGS Library Building; 8.3 Cytosine Deamination; 8.4 RNA Methylation; 9 Future Perspectives; 10 Conclusions; References; Ancient Epigenomics; 1 Introduction; 1.1 Defining Epigenetics; 1.2 The Biological Importance of Epigenetics; 1.3 Molecular Mechanisms Underlying Epigenetic Traits; 1.4 Detecting Epigenetic Marks; 1.5 Factors Influencing Epigenetic Changes; 1.6 Environment-Driven Epigenetic Changes; 2 Early Observations; 2.1 Indirect Indications; 2.2 Direct Observations; 3 The First Ancient Methylomes |
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3.1 The Paleo-Eskimo Saqqaq3.2 Archaic Hominins; 3.3 General Trends; 4 The First Ancient Nucleosome Maps; 5 Implications; 5.1 Sequencing Ancient DNA; 5.2 DNA Damage Models; 5.3 Tissue Specificity and Scarcity; 6 Conclusion and Future Perspectives; References; Part II: Paleogenomics Case Studies: From Ancient Pathogens to Primates; Ancient Pathogens Through Human History: A Paleogenomic Perspective; 1 Introduction; 2 Disease-Associated Pathogens and the Archaeological Record; 3 Using Ancient DNA to Reveal the Imprints of Pathogens |
| Access |
Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK). Uk |
| Terms Of Use |
Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force. Uk |
| Note |
Online resource; title from PDF title page (EBSCO, viewed January 10, 2019). |
| Subject |
Paleobiology.
|
|
Genomics.
|
|
NATURE / Animals / Dinosaurs & Prehistoric Creatures. bisacsh
|
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NATURE / Fossils. bisacsh
|
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SCIENCE / Paleontology. bisacsh
|
| Genre/Form |
Electronic books.
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|
UK eLD e-books IeDuTC
|
| Added Author |
Lindqvist, Charlotte, editor.
|
|
Rajora, Om P., editor.
|
| ISBN |
9783030047535 (electronic bk.) |
|
3030047539 (electronic bk.) |
|
9783030047528 |
|
